2-Bromobutyric Acid: Material Safety Data Sheet

Identification

Product Name: 2-Bromobutyric Acid
Synonyms: Alpha-Bromobutyric acid
Chemical Formula: C4H7BrO2
Molecular Weight: 167.01 g/mol
CAS Number: 80-58-0
Manufacturer: Contact listed supplier or manufacturer for specific details
Recommended Use: Laboratory chemicals, used in organic synthesis
Contact Information: Emergency phone number provided by supplier; Company address and customer support vary by distributor.

Hazard Identification

GHS Classification: Acute Toxicity (Oral) Category 4, Skin Corrosion/Irritation Category 2, Serious Eye Damage/Eye Irritation Category 2A
Label Elements: Warning symbol, exclamation mark (GHS07)
Hazard Statements: Harmful if swallowed; Causes skin and eye irritation
Precautionary Statements: Wash thoroughly after handling; Wear protective gloves, eye protection; Avoid contact with skin, eyes, and clothing
Routes of Entry: Inhalation, skin and eye contact, ingestion
Health Effects: May cause nausea, headache, skin redness, and eye discomfort; Prolonged exposure increases risk.

Composition / Information on Ingredients

Chemical Identity: 2-Bromobutyric Acid
Purity: >98% typical laboratory grade
Ingredients: Contains only the listed organic acid; no significant additives or stabilizers
Impurities: Minor traces of related brominated acids; water under 1% by weight.

First Aid Measures

Inhalation: Remove person to fresh air; seek medical attention if symptoms like headache, coughing, or breathing difficulties develop
Skin Contact: Wash contact area with soap and water for at least 15 minutes; remove contaminated clothing
Eye Contact: Rinse with plenty of water for at least 15 minutes, lifting eyelids occasionally; seek immediate medical assessment
Ingestion: Rinse mouth; do not induce vomiting; call a poison center or physician right away
Notes to Physician: Treat symptomatically; consider possible irritation or corrosive injury.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam
Specific Hazards: May emit toxic fumes of hydrogen bromide, carbon monoxide, and carbon dioxide in fire conditions
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Firefighting Procedures: Move affected containers from fire area if safe; cool exposed containers with water spray
Flash Point: Not available for all grades; approach with caution.

Accidental Release Measures

Personal Precautions: Wear gloves, eye protection, and laboratory coat; ventilate spill area well
Environmental Precautions: Prevent material from entering drains, surface water, or soil
Containment and Cleanup: Absorb spill with inert material (vermiculite, sand); scoop into labeled waste container
Decontamination: Wash surfaces thoroughly with water and mild detergent after material removal
Disposal: Follow disposal procedures for hazardous organic acid waste under local, national, and international guidelines.

Handling and Storage

Precautions for Safe Handling: Handle in well-ventilated area; avoid breathing vapors, dust, or mist; avoid all direct contact with skin and eyes; do not eat, drink, or smoke during use
Hygiene Measures: Wash hands and face after handling; remove contaminated clothes and wash before reuse
Conditions for Safe Storage: Store tightly closed in a cool, dry, well-ventilated area, away from direct sunlight, sources of ignition, incompatible substances (oxidizing agents, strong bases); protect from moisture
Storage Limits: Use corrosion-resistant shelves and secondary containment to limit accidental damage.

Exposure Controls and Personal Protection

Occupational Exposure Limits: No known specific limit set by OSHA, NIOSH, or ACGIH for this chemical; minimize exposure based on general acid safety
Engineering Controls: Use fume hood, laboratory exhaust, or local ventilation
Personal Protective Equipment: Gloves (nitrile or butyl rubber), chemical splash goggles, lab coat, closed shoes; consider face shield for splash hazards
Respiratory Protection: Use approved respirator if vapors or aerosol concentrations become excessive
Monitoring: Regular inspection of work area and air quality as appropriate for laboratory standards.

Physical and Chemical Properties

Appearance: Colorless to pale yellow clear liquid or low-melting solid
Odor: Pungent, acid-like
Melting Point: 46–50°C
Boiling Point: 206–210°C
Flash Point: >100°C (check with supplier batch)
Solubility: Miscible or sparingly soluble in water; soluble in organic solvents like ethanol and ether
Density: About 1.7 g/cm³
pH: Acidic in solution
Vapor Pressure: Very low at standard temperatures
Partition Coefficient: log Pow not readily available; likely to favor organic phase due to nonpolar region.

Stability and Reactivity

Chemical Stability: Stable under recommended use and storage conditions; breaks down on exposure to heat, strong bases, strong oxidizing agents
Incompatibilities: Reacts vigorously with strong bases, oxidizers, reducing agents, and some metals; can corrode metal if stored improperly
Hazardous Decomposition Products: Releases hydrogen bromide, carbon oxides, and potentially irritating organic vapors upon decomposition
Polymerization Risks: Does not polymerize under normal conditions.

Toxicological Information

Acute Toxicity: Oral LD50 (rat): 1580 mg/kg (literature); can cause moderate to severe irritation; symptoms include nausea, vomiting, diarrhea, headache
Skin Corrosion/Irritation: Irritant; prolonged contact may lead to redness or blistering
Serious Eye Damage/Irritation: Causes significant irritation; pain, swelling
Respiratory Sensitization: Not a known respiratory sensitizer but inhalation should be avoided
Chronic Exposure: No well-studied effects; keep exposure as low as possible
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified by IARC, NTP, or OSHA for cancer risk; no reliable data on chronic hazards
Routes of Exposure: Eyes, skin, ingestion, inhalation; avoid direct or repeated contact.

Ecological Information

Aquatic Toxicity: Moderately toxic to aquatic organisms according to available data for similar compounds
Persistence and Degradability: Degrades in the environment over time, but potential for toxicity remains until breakdown
Bioaccumulation: No strong evidence for significant bioaccumulation; chemical structure suggests limited risk, but absence of long-term studies leaves uncertainty
Mobility in Soil: Expected to migrate slowly in soil; most acid will bind to soil or degrade
Other Adverse Effects: Do not discharge to waterways, public sewers, or uncontrolled sites without treatment.

Disposal Considerations

Waste Treatment Methods: Collect waste in sealed, properly labeled containers for hazardous organics
Sewage Disposal: Never dispose of via drain; consult local regulations and environmental authorities
Incineration: Suitable option at approved hazardous waste facility
Contaminated Packaging: Decontaminate or dispose of as hazardous waste
Regulatory Advice: Follow local, state, national, and international waste management laws for organic chemicals.

Transport Information

UN Number: UN3265
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains 2-Bromobutyric Acid)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II or III, depending on concentration and container size
Marine Pollutant: Not classified but avoid release to environment
Special Precautions: Use approved containers; protect from physical damage; keep away from incompatible materials during transport; follow shipping instructions for hazardous chemicals.

Regulatory Information

OSHA: Not specifically regulated, requires hazard communication actions (GHS labeling)
SARA Title III: Not subject to reporting under Sections 302, 304, 313
TSCA: Listed in Chemical Inventory
REACH (EU): Substance registration requirements apply; check with supplier on status
Other Regulations: Subject to lab chemical safety rules, hazardous substance handling and transportation regulations; employers responsible for workers’ right-to-know and safety training
Labeling: Follow all prescribed precautionary and hazard warnings for laboratory and transport uses.