Material Safety Data Sheet for 4-Bromotoluene

Identification

Product Name: 4-Bromotoluene
Chemical Formula: C7H7Br
Chemical Family: Aromatic brominated hydrocarbon
Synonyms: p-Bromotoluene, 1-Bromo-4-methylbenzene, para-Bromotoluene
CAS Number: 106-38-7
Recommended Use: Laboratory reagent, organic synthesis intermediate
Manufacturer/Supplier: Contact details must be on original supplier documentation
Emergency Contact Number: Provided by distributor or local emergency services

Hazard Identification

Hazard Classification: Flammable liquid, harmful if inhaled, eye and skin irritant
Label Elements: Signal word: Warning; pictograms: exclamation mark, flame
Hazard Statements: May cause respiratory irritation; causes skin and eye irritation; flammable liquid and vapor
Precautionary Statements: Keep away from heat sources, wear protective gloves and eyewear, avoid breathing vapors
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Effects of Overexposure: Headache, dizziness, coughing, red or itchy skin, eye discomfort
NFPA Ratings: Health: 2; Flammability: 2; Reactivity: 0; Specific: none

Composition / Information on Ingredients

Chemical Name: 4-Bromotoluene
CAS Number: 106-38-7
Concentration: 99% or higher in supplied form
Impurities: Trace levels of other brominated toluenes possible
Stabilizers/Additives: None reported by major suppliers

First Aid Measures

Eye Contact: Rinse gently with plenty of water for at least 15 minutes; remove contact lenses; seek medical help
Skin Contact: Wash with soap and water; remove contaminated clothing and footwear; get medical attention for persistent irritation
Inhalation: Move person to fresh air; keep warm and at rest; seek medical advice if symptoms appear
Ingestion: Rinse mouth with water; get medical attention immediately; do not induce vomiting unless instructed by professionals
Most Important Symptoms/Effects: Irritation, headaches, dizziness, coughing
Notes for Physician: Treat symptomatically; no specific antidote known

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide; use water spray to cool containers
Unsuitable Extinguishing Media: Direct stream of water may spread fire
Specific Hazards: Vapors can form explosive mixtures with air; combustion releases toxic bromine and carbon monoxide
Special Protective Equipment: Wear self-contained breathing apparatus (SCBA) and protective suit
Firefighting Instructions: Evacuate area, fight fire from a safe distance, prevent runoff into drains
Hazardous Combustion Products: Hydrogen bromide, carbon oxides, dense irritating smoke

Accidental Release Measures

Personal Precautions: Avoid contact with skin and eyes; ventilate area; wear suitable protective clothing and gloves
Environmental Precautions: Prevent further spillage or leakage; keep material out of soil, drains, and water sources
Methods for Cleaning Up: Absorb with inert material (sand, earth); collect into containers for disposal; wash spill site with suitable detergent
Emergency Procedures: Only trained personnel equipped with appropriate PPE should manage significant releases
Evacuation: Large spills demand area evacuation until safe

Handling and Storage

Safe Handling Advice: Avoid inhaling vapors or fumes; handle in well-ventilated area; minimize spillage and splashing
Preventive Measures: Keep away from ignition sources and incompatible materials; avoid static discharge
Hygiene Measures: Wash thoroughly after use; do not eat or drink when handling chemicals; use dedicated work clothing
Storage Conditions: Store in cool, dry, well-ventilated place; keep container tightly closed; store away from oxidizing agents and acids
Container Requirements: Use proper, clearly labeled containers made from compatible material; keep upright and secure

Exposure Controls and Personal Protection

Engineering Controls: Use chemical fume hood; provide local exhaust ventilation if working on scale
Exposure Limits: No established OSHA or NIOSH exposure limits; minimize exposure to all chemical vapors
Respiratory Protection: Use NIOSH-approved respirators if ventilation inadequate
Eye Protection: Wear safety goggles or face shield
Skin Protection: Use chemical-resistant gloves (nitrile or neoprene), lab coat or apron
General Protection: Use eye wash and safety shower stations nearby

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Mild aromatic odor
Odor Threshold: Data not available
pH: Not applicable
Melting Point: -1°C
Boiling Point: 184°C
Flash Point: 52°C (closed cup)
Evaporation Rate: Data not available
Flammability: Flammable
Upper/Lower Explosion Limits: Data not available
Vapor Pressure: 1 mmHg @ 29°C
Vapor Density: 5.3 (air = 1)
Solubility in Water: Negligible
Partition Coefficient (log Kow): 3.7
Auto-Ignition Temperature: 520°C
Decomposition Temperature: No information
Viscosity: Not measured

Stability and Reactivity

Chemical Stability: Stable under normal operating conditions
Reactivity: Reacts with strong oxidizers; potential for slow corrosive action with certain metals
Hazardous Reactions: No dangerous reactions expected if handled as recommended
Incompatible Materials: Strong acids, oxidizing agents, alkali metals
Hazardous Decomposition: Decomposes to hydrogen bromide, carbon oxides at high temperature or fire

Toxicological Information

Acute Toxicity: Oral LD50 (rat) approx. 1400 mg/kg; inhalation and dermal toxicity not well documented
Skin Irritation: May cause redness and dryness
Eye Irritation: Causes discomfort, tearing
Sensitization: Data not available on allergic reaction
Repeated Exposure: Prolonged contact can defat skin and cause dermatitis
Chronic Toxicity: No evidence of carcinogenic or mutagenic effects in available studies
Target Organs: Eyes, skin, respiratory system
Other Information: Avoid unnecessary exposure; toxic effects are more common with large or repeated doses

Ecological Information

Toxicity to Aquatic Life: Harmful to aquatic organisms; may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Not readily biodegradable; persists under environmental conditions
Bioaccumulation Potential: Moderate (high log Kow suggests possible accumulation in organisms)
Mobility in Soil: Low due to hydrophobicity; likely to adsorb strongly to soil
Other Adverse Effects: Discharge to natural waters must be avoided to protect aquatic ecosystems

Disposal Considerations

Waste Disposal Methods: Dispose in accordance with national, regional, and local regulations; do not pour down drains
Hazardous Waste: May qualify as hazardous waste; consult regulations
Container Disposal: Empty containers must be handled as hazardous—triple rinse, then offer for permitted reconditioning or disposal
Special Precautions: Label waste containers clearly; segregate incompatible waste streams

Transport Information

UN Number: UN 1993
Transport Name: Flammable liquid, n.o.s. (contains 4-Bromotoluene)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Marine Pollutant: Yes—harmful to aquatic life
Proper Shipping Label: Class 3 flammable liquid
Transportation Precautions: Keep upright, away from foodstuffs and incompatible cargo

Regulatory Information

OSHA Status: Regulated under Hazard Communication Standard (29 CFR 1910.1200)
SARA 313: Not listed specifically; check supplier documentation
TSCA Inventory: Listed
REACH Status: Registered in the EU
DOT Regulations: Subject to regulations for flammable liquids
EPA Regulations: Subject to requirements under Clean Water Act for toxic substances
Other Country Inventories: Present on major international inventories; compliance required with region-specific requirements