Material Safety Data Sheet: Bromobenzene

Identification

Product Name: Bromobenzene
Chemical Name: Monobromobenzene
Synonyms: Phenyl Bromide
CAS Number: 108-86-1
Recommended Use: Laboratory reagent, organic synthesis
Manufacturer: Information available from supplier
Emergency Contact Number: Provided by supplier or regulatory agency

Hazard Identification

GHS Classification: Flammable liquids (Category 3), Acute toxicity (Category 4, Oral and Inhalation), Eye irritation (Category 2A), Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed or inhaled. Causes skin and serious eye irritation.
Pictograms: Flame, Exclamation mark
Precautionary Statements: Avoid breathing dust, vapor, or mist. Keep away from heat, sparks, open flames, and hot surfaces. Wear protective gloves, clothing, and eye/face protection.
Potential Health Effects: Irritation to eyes and skin. Harmful effects on central nervous system possible with significant exposure.

Composition / Information on Ingredients

Chemical Identity: Bromobenzene
CAS Number: 108-86-1
Concentration: 99-100%
Impurities/Additives: No significant impurities with known toxicological effects reported in reagent-grade material

First Aid Measures

Inhalation: Move affected person to fresh air. Seek medical attention if breathing becomes difficult or irritation persists.
Skin Contact: Remove contaminated clothing. Wash skin with soap and water for at least 15 minutes. Get medical aid for irritation.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.
Ingestion: Rinse mouth. Do not induce vomiting. Seek immediate medical attention.
Most Important Symptoms: Burning sensation, coughing, headache, dizziness in severe cases.

Fire-Fighting Measures

Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical, or carbon dioxide.
Unsuitable Media: Water jet can spread the fire.
Specific Hazards: Vapors are heavier than air and can travel to source of ignition. Decomposition produces hydrogen bromide and carbon oxides.
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear. Fire can produce irritating or toxic fumes.
Special Procedures: Cool containing vessels with water spray to prevent pressure build-up.

Accidental Release Measures

Personal Precautions: Wear chemical-resistant gloves, splash goggles, and protective clothing. Avoid inhalation and contact with skin or eyes.
Environmental Precautions: Prevent spills from entering drains or waterways.
Methods for Clean-Up: Contain spillage with non-combustible absorbent (sand, earth, vermiculite). Collect in sealable containers. Wash area with soap and water.
Ventilation: Ensure adequate ventilation during clean-up.

Handling and Storage

Safe Handling: Avoid breathing vapors or contact with skin and eyes. Use only with adequate ventilation. Ground and bond containers when transferring.
Storage Conditions: Store in tightly closed glass or plastic containers in a cool, dry, well-ventilated area away from heat sources or open flames. Protect from sunlight and moisture.
Incompatible Materials: Strong oxidizers, strong bases, alkali metals, reducing agents

Exposure Controls and Personal Protection

Occupational Exposure Limits: No OSHA or ACGIH limits established for bromobenzene; workplace levels should be monitored to stay as low as possible.
Engineering Controls: Use fume hood, explosion-proof equipment, and local exhaust ventilation.
Personal Protective Equipment: Chemical safety goggles, impervious gloves (nitrile or neoprene), flame-resistant lab coat, suitable respiratory protection where vapor concentrations are high.
Hygiene Measures: Wash hands after handling. Remove and wash contaminated clothing before reuse. Keep work area clean and uncluttered.

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Aromatic, characteristic odor
Melting Point: -30.6 °C
Boiling Point: 156 °C
Vapor Pressure: 1.27 kPa at 25 °C
Density: 1.495 g/cm³
Solubility: Insoluble in water; soluble in alcohol, ether, benzene, and other organic solvents
Flash Point: 48 °C (closed cup)
Autoignition Temperature: 566 °C
Explosion Limits: 1.0% to 9.2% (v/v) in air
Viscosity: Not highly viscous

Stability and Reactivity

Stability: Stable under normal conditions of storage and use.
Hazardous Polymerization: No hazardous polymerization expected.
Decomposition Products: Hydrogen bromide gas, carbon monoxide, carbon dioxide
Incompatible Materials: Strong oxidizing agents, strong bases, alkali metals
Conditions to Avoid: High temperatures, contact with ignition sources, prolonged exposure to light

Toxicological Information

Acute Toxicity: Oral LD50 (rat): 3160 mg/kg; Inhalation LC50 (rat, 4hr): 17.7 mg/L
Irritation: Causes moderate to severe irritation to eyes and skin.
Sensitization: No evidence from studies of skin or respiratory sensitization.
Chronic Effects: Prolonged or repeated exposure may affect liver, kidneys, and nervous system.
Carcinogenic Status: Not listed as a carcinogen by IARC, NTP, or OSHA.
Mutagenicity: Inconclusive data on mutagenic effects.
Routes of Exposure: Inhalation, skin and eye contact, and ingestion

Ecological Information

Acute Aquatic Toxicity: Harmful to aquatic life; 96-hour LC50 (fish) ~41 mg/L
Biodegradability: Not rapidly biodegradable; can persist in environment
Bioaccumulation Potential: Moderate bioaccumulation expected
Mobility in Soil: Low mobility expected due to low water solubility
Other Adverse Effects: Toxic to aquatic organisms at higher concentrations

Disposal Considerations

Waste Treatment Methods: Burn in chemical incinerator equipped with afterburner and scrubber, observing all federal, state, and local environmental regulations.
Container Disposal: Puncture and drain containers. Offer to licensed hazardous waste contractor for recycling or disposal.
Precautions for Disposal: Avoid disposal in drains, sewers, or natural water systems. Consult regional authorities for detailed advice.

Transport Information

UN Number: UN 2515
Proper Shipping Name: Bromobenzene
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Environmental Hazards: Marine pollutant in bulk quantities
Special Precautions: Keep away from food, feedstuff, and incompatible goods during transport. Use approved containers, secure tightly.

Regulatory Information

OSHA Status: Hazardous chemical as per 29 CFR 1910.1200
SARA Title III: Listed under Section 313 for specific reporting requirements
TSCA Inventory: Listed
EPA Hazard Categories: Immediate (acute) health hazard, Fire hazard
California Proposition 65: Not listed as a chemical requiring warning
Other Regulations: Follow specific local, regional, and national regulations regarding storage, handling, and disposal. Consult Safety and Environmental Health staff for guidance in regulatory compliance.